Neuro Optimizer 60cps

Ce este Neuro Optimizer?

Asociere de ingrediente ce ajuta la sustinerea sistemului nervos si imbunatatirea memoriei, concentrarii si atentiei.

Ce conține și ce beneficii oferă?

  • Contine Cognizin® (Citidina 5-difosfocolina, citicolina, CDPcolina), ingredient patentat si studiat clinic. Cognizin® poate creste productia de ATP (creste nivelul de energie) de la nivelul creierului cu pana la 14% si poate oferi suport in formarea de noi membrane celulare cerebrale cu pana la 26% la adulții sanatosi (1)**
  • Contine Cognizin® (Citidina 5-difosfocolina (citicolina, CDPcolina), ingredient patentat si studiat clinic. Cognizin poate imbunatati atentia si viteza psihomotorie (functiile motrice realizate prin activitatea nervoasă superioară) si poate reduce impulsivitatea la adolescentii de gen masculin, dependent de concentratie (1)***
  • Formula imbunatatita cu: fosfatidilserina, fosfatidilcolina, L-glutamina, taurina, acetil L-carnitina si acid alfa lipoic (elemente bioactive care pot ajuta la mentinerea capacitatii de invatare, memorare si redare a informatiilor(2), a fluiditatii verbale, concentrarii, vigilentei si atentiei (3)
  • Contine vitamina B5, care contribuie la performanta mentala normala, la reducerea oboselii si extenuarii, la sinteza normala si metabolizarea unor neurotransmitatori
  • Actioneaza ca suport in cazurile de profilaxie si tratament complementar al traumatismelor cranio-cerebrale moderate sau grave (4)

**(1) Efectul Cognizin® citicolina imbunatateste metabolismul energetic(ATP) de la nivel cerebral si producerea de membrane cerebrale la adulții sanatosi in studiul desfasurat de Societatea de Neurostiinte din San Diego, California, pe o perioada de 6 saptamani, pe un esantion de 16 pacienti.

***(1) Efectul suplimentarii cu Cognizin® citicoline asupra vitezei de reactie si a atentiei la barbatii adolescenti in studiul desfasurat de Universitatea din Utah, Salt Lake City, pe o perioada de 28 de zile

 (2) Cai-Ling Lu, Shen Tang, Zhi-Juan Meng, Yi-Yuan He, Ling-Yong Song, Yin-Pin Liu, Ning Ma, Xi-Yi Li; Taurine improves the spatial learning and memory ability impaired by sub-chronic manganese exposure; Journal of Biomedical Science; 2014; 21(1): 51

(3) MK Gestuvo; WW Hung; Common Dietary Supplements for Cognitive Health; Aging Health. 2012;8(1):89-97.

(4) Efectul produsului Neuro Optimizer ca suport in tratamentul pacientilor cu TCC moderat sau grav constatate sub aspect clinic-observational, retrospectiv in studiul desfasurat, in perioada ianuarie-noiembrie 2015, pe un lot de studiu 38 subiecti raportat la un lot martor de 47 subiecti din perioada 2005-2014, La Spitalul Clinic de Urgenta “Bagdasar-Arseni” (SCUBA), Bucuresti, Romania.

Prin asocierea complexă de ingrediente, Neuro Optimizer contribuie la:

  • Cognizin® oferă suport în:

–        mentinerea structurii si functiilor cerebrale (2)

–        pastrarea integritatii structurii, permeabilitatii si fluiditatii membranelor celulelor nervoase prin sustinerea sintezei fosfatidilcolinei, componenta majora a materiei cenusii (2)

–      mentinerea capacitatii de invatare, memorare si redare a informatiilor, a fluiditatii verbale, concentrarii, vigilentei si atentiei, la imbunatatirea starii emotionale, sociabilitatii, adaptabilitatii, capacitatii motorie, prin suport in sinteza si mentinerea nivelului neurotransmitatorilor acetilcolina, dopamina, adrenalina, noradrenalina, si a cresterii sensibilitatii receptorilor (2)

–      stimularea neurogenezei si regenerarea neuritilor (prelungiri ale neuronului) prin actiune similara cu a factorilor de crestere neuronali; poate sustine reducerea degenerarii neuronilor sanatosi, stimularea factorului neurotrofic derivat din creier – BDNF (efect neuroplastic) (3)

–         refacerea neurologica dupa interventii chirurgicale, traumatisme cerebrale sau craniene, epuizare (3)

–       reducerea anxietatii, stresului, avand capacitatea de a mentine nivele echilibrate de cortizol, prin actiune pe axa hipotalamus-hipofiza-suprarenale si de hormon luteinizant, progesteron si testosteron (3)

–           reducerea manifestarilor date de afectarea nervilor cranieni (3)

–           imbunatatirea activitatii electrice a creierului prin stabilizarea undelor celebrale (4)

  • Citicolina oferă suport in:

–           reducerea edemelor si imbunatatirea circulatiei cerebrale (20)

–           reducerea demielinizarii (pierderea stratului de mielina care contribuie la protejarea si hranirea celulei nervoase) (20)

–           reducerea complicatiilor neurologice cauzate de concentratia mare a glucozei din sange si de administrarea xenobioticelor (1)

  • Glutamina ofera suport in reducerea neurotoxicităţii date de excesul de glutamat (neurohormon excitator), lipofuscină (produs de degradare celulară neeliminată din organism), cu efect neuroprotectiv (11)
  • Acetil L-carnitina ofera suport în:

–         cresterea cantitatii de glucoza metabolizata de creier si rata de folosire a oxigenului prin participarea la metabolismul mitocondrial. Intrucat creierul nu are rezerve de energie acesta este dependent de cantitatea de glucoza metabolizata pentru a functiona normal. Desi reprezinta doar 2 la suta din masa noastra corporala, creierul consuma 20 la suta din cantitatea de energie pe care o produce organismul, adica de zece ori mai multa decat orice alt organ (21)

–           sustinerea protectiei antioxidante cerebrale impotriva distrugerilor neuronilor (21)

Studii clinice:

Efectele Cognizin®-ului la nivel cerebral au fost evaluate prin numeroase studii. Cercetatorii de la Brain Imaging Center din cadrul spitalului McLean din Boston, in colaborare cu cei de la Harvard, sub aspect clinic observational, au urmarit timp de 6 saptamani efectele Cognizin®-ului asupra memoriei si atentiei pe un lot de 16 persoane cu varsta mijlocie. Cercetatorii au observat o crestere cu 26% a ratei de formare de membrane neuronale, determinand si o crestere a energiei folosite la nivelul neuronilor, cu un procent de 13,6%. **

**MM Silveri, J Dikan, AJ Ross, JE Jensen, T Kamiya, Y Kawada, PF Renshaw, DA Yurgelun-Todd; Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy; NMR Biomed. 2008 Nov;21(10):1066-75.

Efectele Cognizin®-ului la nivel cerebral au fost evaluate prin numeroase studii.  Cercetatorii de la University of Utah, Salt Lake City, UT, USA, sub aspect observational, au urmarit timp de 28 de zile efectele Cognizin® citicolina asupra vitezei de reactie si a atentiei la 75 de adolescenti de gen masculin (51 au facut parte din grupul de studiu si 24 din grupul placebo). Cercetatorii au observat ca citicolina a crescut viteza motorie si a imbunatit atentia la grupul de studiu, comparativ cu placebo, dependent de concentratie.***

***Erin McGlade, Anna Monica Agoston, Jennifer DiMuzio, Miho Kizaki, Eri Nakazaki, Toshikazu Kamiya, Deborah Yurgelun-Todd; The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males; First Published July 15, 2015.

            Referinte:

  1. http://www.purenootropic.com/cholinergics/citicoline/\
  2. http://www.encognitive.com/files/The%20Ultimate%20Brain%20Nutrient%20Cognizin%20Citicoline.pdf Sherrill Sellman, ND; The Ultimate Brain Nutrient Cognizin Ctiticoline.
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695184 Mario Fioravanti and Ann E.Buckley; Citicoline (Cognizin) in the treatment of cognitive impairment; Clin Interv Aging. 2006 Sep; 1(3): 247–251.
  4. https://kyowa-usa.com/news/2009/06-11
  5. http://file.scirp.org/pdf/FNS20120600007_87495447.pdf Erin McGlade, Allison Locatelli, Julia Hardy, Toshikazu Kamiya, Masahiko Morita, Koji Morishita, Yoichiro Sugimura, Deborah Yurgelun-Todd; Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women; Food and Nutrition Sciences, 2012, 3, 769-773.
  6. https://www.ncbi.nlm.nih.gov/pubmed/26179181 McGlade E, Agoston AM, DiMuzio J, Kizaki M, Nakazaki E, Kamiya T, Yurgelun-Todd ; The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males; J Atten Disord. 2019 Jan;23(2):121-134.
  7. https://pdfs.semanticscholar.org/b0f2/fac0b6f22798d69f8b16152403a7e5544146.pdf Neeta Kumari, Howard Prentice, and Jang-Yen Wu. Taurine and Its Neuroprotective Role.
  8. https://www.ncbi.nlm.nih.gov/pubmed/23392923 Chan CY, Sun HS, Shah SM, Agovic MS.Direct interaction of taurine with the NMDA glutamate receptor subtype via multiple mechanisms,Adv Exp Med Biol. 2013;775:45-52.
  9. https://www.sciencedirect.com/science/article/abs/pii/0024320587900981 Avital Schurr., Michael T. Tseng, Catherine A. West.Taurine improves the recovery of neuronal function following cerebral hypoxia, Life Science 25 May 1987, Pages 2059-2066.
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899466/ Janusz W. Błaszczyk.Parkinson’s Disease and Neurodegeneration: GABA-Collapse Hypothesis. Front Neurosci. 2016; 10: 269.
  11. https://www.ncbi.nlm.nih.gov/pubmed/22413000 Chen J, Herrup K (2012) Glutamine Acts as a Neuroprotectant against DNA Damage, Beta-Amyloid and H2O2-Induced Stress.
  12. https://www.spandidos-publications.com/10.3892/mmr.2018.9465 Xiaoli Niu, Simin Zheng, Hongtao Liu, Siyuan Li; Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury; Molecular Medicine Reports; published on: September 6, 2018; pages: 4516-4522.
  13. https://www.nature.com/articles/s41598-017-02957-w Bryant J. Jongkees, Maarten A. Immink, Lorenza S. Colzato; Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial; Scientific Reports; volume 7, Article number: 2693; 2017.
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981104/ Yael Richter, Yael Herzog, Tzafra Cohen and Yael Steinhart; The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study; Clin Interv Aging. 2010; 5: 313–316.
  15. https://www.nature.com/articles/s41598-017-02957-w Bryant J. Jongkees, Maarten A. Immink, Lorenza S. Colzato; Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial; Scientific Reports; volume 7, Article number: 2693; 2017.
  16. https://www.sciencedirect.com/science/article/pii/S0304416509002153 Kate Petersen Shay, Régis F.Moreau, Eric J.Smith, Anthony R.Smith, Tory M.Hagen; Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential; Biochimica et Biophysica Acta (BBA) – General Subjects; Volume 1790, Issue 10, October 2009, Pages 1149-1160.
  17. https://academic.oup.com/brain/article/138/11/e388/330360 Pawel Grieb; Beneficial effects of exogenous CDP-choline (citicoline) in EAE; Brain, Volume 138, Issue 11, 1 November 2015, Pages e388.
  18. https://www.ncbi.nlm.nih.gov/pubmed/22018046 Albrecht J, Sidoryk-Węgrzynowicz M, Zielińska M, Aschner M.; Roles of glutamine in neurotransmission; Neuron Glia Biol. 2010 Nov;6(4):263-76.
  19. https://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1520-6866(1998)18:4%3C153::AID-TCM1%3E3.0.CO;2-P Denise Crispim Tavares, Andréa O. Cecchi, Lusania M. G. Antunes, Catarina S. Takahashi; Protective effects of the amino acid glutamine and of ascorbic acid against chromosomal damage induced by doxorubicin in mammalian cells; Volume 18, Issue 4; 1998; pages 153-161
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  21. https://www.sciencedirect.com/topics/neuroscience/acetylcarnitine Scott D. Mendelson M.D., Ph.D., in Metabolic Syndrome and Psychiatric Illness, 2008

 

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